The research landscape of immunology research in spinal cord injury from 2012 to 2022

Background Spinal cord injury (SCI) is defined as traumatic damage to the spinal cord, affecting over three million patients worldwide, and there still no treatment for injured itself. In recent years, immunology research on SCI has been published in various journals. Methods To systematically analyze hotspots dynamic scientific developments of SCI, we conducted a bibliometric knowledge map analysis help researchers gain global perspective this field. Results The study completed included 1788 English-language papers 553 journals by 8861 authors from 1901 institutions 66 countries/regions. Based references keyword analysis, past 10 years have mainly focused directions “monocyte chemoattractor protein 1,” “nitric oxide,” “pain,” oxide synthase” related immunological SCI. However, with development other new such “extracellular vesicles” (2019–2022), “Regenerative medicine” “stromal cells” (2018–2022), “motor recovery” “glial activation” (2019–2022). Researchers prefer application regenerative strategies mechanism extracellular vesicles activation glial cells pathways motor recovery. This summarizes current status relationship between vesicles, medicine, stromal cells, recovery, currently major frontier. Further cooperation worldwide need be enhanced. Conclusion We believe that our can quickly grasp hotspot determine direction future research.